Cell Reports has published a new research in its journal which says that combination of a drug could kill cancerous cells by cutting off its energy supply.
Cancer cells require quite an amount of energy to multiply. A common diabetes type 2 drugs, metformin works to reduce the blood sugar by reducing the pace of glucose release from liver as also the sugar absorption in the gut from food.
The drug is also effective in treating insulin resistance. It also treats obesity and helps losing weight in people who are not diabetic or pre-diabetic.
Scientists have discovered several uses of metformin. It helps cure polycystic ovary. Also it is advocated by some researchers to be effective in improving fertility and for regularization of menstrual cycle.
Metformin studies conducted on animals revealed that the drug is likely to influence the metabolism related with aging and similar conditions and currently researches are underway to study the effect of metformin in longevity of human life.
2 years back, Biozentrum researchers from University of Basel, Switzerland discovered that metformin when combined with a high BP drug could prevent growth of cancer tumors.
As per the latest research, scientists reveal that the combination of antihypertensive syrosingopine and metformin kills cancer cells by curbing energy supply to cancerous cells.
The study took place at Biozentrum in association with BSIL (Basilea Pharmaceutica International Ltd).Biozentrum’s Don Benjamin has been the study’s 1st author.
Metformin dose used for diabetes cannot prevent tumor growth. But when combined with BP drug, it enhances the anti-cancerous properties.
According to the scientists, this happens because cancer cells require energy to multiply and spread. However, NAD+, a molecule acts as an obstacle that thwarts the tumor’s metabolic requirements. NAD+ is responsible for converting nutrients into energy. Metofomin and the BP drug syrosingopine restrict regeneration of NAD+, albeit in different ways. This creates an energy shortage for the cancer cells, which ultimately prevents the cancerous cells to grow and thrive.